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St. John’s Wort

St. John’s Wort

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St. John's Wort

• Introduction:
Supports a positive mood.†
Contains 0.3% hypericin.
In the tablet form as used in the clinical studies.
Made in USA in GMP facilites.
One bottle lasts for one month.
All specifications same as used in the clinical trials to reproduce the positive outcome.
May be as effective as Prozac yet with less side effect. †

300 mg standardized extract 90 tablets per bottle.

St. John's Wort (Hypericum perforatum, 圣约翰草) is the most commonly used herb in USA and in Europe to maintain a positive mood. It is prescribed in Germany 20 times more often than Prozac for treatment of depression. Clinical research has shown that standardized St. John’s Wort extract helps improve symptoms related to depression.† It has few side effect. However, caution needs to be taken if you are taking other prescription drugs because drug interactions have been noticed.

St. John’s Wort Health Benefits:
Many clinical trials have been conducted by researchers in USA and Europe to evaluate the use of St. John's Wort as antidepressant. In a meta analysis of St. John's Wort clinical trials, 23 randomized, placebo or antidepressant drug controlled trials were identified, of which 20 trials were further double blinded. The analysis revealed that all but two trials showed that St. John's Wort is significantly superior to placebo and is as effective as antidepressants in the treatment of mild and moderate depression.

In a subsequent, well publicized trial funded by NIH, however, St. John's Wort was found no better than placebo. What the media failed to mention to the public was that in the same trial sertraline, a standard antidepressant approved by FDA, was no better than placebo too, which means even a known antidepressant did not work in the trial, suggesting the trial simply did not work and does not actually tell anything about St. John's Wort. It is noteworthy that in the trial the patients are all in major depressive disorder.

It comes to 2005 when a new and well publicized trial was released. Here 251 patients with acute major depression were randomized to receive either a St. John's Wort standardized extract, or popular antidepressant drug Prozac in a double blinded manner. Both St. John's Wort and Prozac were used in their standard dose for 6 weeks. The results shows that St. John's Wort is at least as effective as Prozac in the treatment of depression yet has less side effect.

Active Ingredients
Research on St. John's Wort mostly uses standardized extracts made from its dry flowers and stems. The standardized extracts are concentrated 5-7 times and typically contains 0.3% hypericin, which is believed to be the active ingredient of St. John's Wort. Sometimes St. John's Wort extracts are standardized to 2-4.5% hyperforin, which was suggested by some research to be the active ingredient. Nevertheless, most research and clinical trials have used standardized St. John's Wort extract at 0.3% hypericin.

Dose and Duration:
In the St. John's Wort clinical trials, patients typically took 900 mg standardized extract per day, divided in 3 times. In case the body is not responding, the dose were often raised to 1800 mg. The trials commonly last for 6 to 8 week.

Use Discretion:

St. John’s Wort Side Effects:
Side effects are few in the St. John's Wort clinical trials and less common than the antidepressant drugs such as Prozac. However, the following mild adverse reactions were occasionally observed: upper abdominal pain, diarrhoea, dry mouth, nausea, fatigue, dizziness, headache, sleep disorder and sweating.

St. John's Wort Drug Interaction:
Numerous studies suggest that St. John's Wort may interact with other prescription drugs to weeken their effects. Examples may include: anti-HIV drug indinavir, the immunosuppressant drug cyclosporine, anticoagulants like warfarin, anti-cancer drugs like irinotecan. So caution needs to be taken if you are on other medications.

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